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The primary molecular actions relevant to skin are: modulation of TGF- signaling (upregulating TGF-1 for collagen I/III synthesis while suppressing TGF-2 to prevent scarring), decorin upregulation for orderly collagen fibril assembly, MMP suppression paired with TIMP upregulation to preserve ECM integrity, and copper-dependent lysyl oxidase activation for collagen crosslinking

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While medication one day past the BUD may still be effective, you have no way to verify this without laboratory testing

Lassey said there is not enough long-term research at this point to know how the medications may impact fertility